David Collister

Preferences Regarding Treatment with Plasma Exchange for ANCA-Associated Vasculitis: An International Patient Survey

Tell us about yourself, your research and why this interests you.

I am studying patient values and preferences regarding plasma exchange as a treatment for ANCA associated vasculitis. It is interesting because it helps inform shared decision making and individualizing treatment as a kidney doctor.

What’s been most rewarding to you as an investigator?

Most rewarding: generating evidence that informs clinical care.  Fun Fact: I have been trying to learn Mandarin since the COVID-19 pandemic started.

Why is your research important to patients?

This research study focused on patient values and preferences regarding plasma exchange (also known as plasmapheresis) as a treatment for ANCA-associated vasculitis. We found there was considerable variability in patients’ choices: 1/3 of respondents chose plasma exchange regardless of risk, 1/5 of respondents chose plasma exchange but only at higher risks, and 1/6 of respondents declined plasma exchange under any situation. Predictors of choosing treatment with plasma exchange were previous treatment with dialysis, previous treatment with plasma exchange, risk of kidney failure or serious infection, and country. Our findings show that there is a need to engage in shared decision-making between patients and physicians when considering plasma exchange in ANCA-associated vasculitis including for patients at both high and low risk of kidney failure.

How was the VPPRN used in your research study?

The VPPRN played a vital role in this research study. The study design was comprised of a survey circulated among members of the VPPRN and partnering organizations. The project team included a VPPRN Patient Research Partner (Paul Brown) who was helpful in the design of the survey and interpretation of the results.

This study would not have been possible without the participation of members of the VPPRN. As a result of their participation, we are able to execute research studies like this that provide practitioners data to better understand vasculitis leading to improved care and outcomes for patients with vasculitis.

The findings from this research study are a direct result of the participation, engagement, and health information provided by members of the VPPRN!