Clinical Trial for ANCA-Associated Vasculitis – Now Enrolling Patients

Sites throughout the U.S. and Canada are seeking patients with newly diagnosed or relapsed anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.  This clinical trial is designed to determine whether a new non-steroidal treatment, when added to standard of care treatment can improve the remission rate, kidney function, and/or improve vasculitis symptoms.  All patients will receive standard treatment more »

RITAZAREM Trial – Now Enrolling Patients

The RITAZAREM Trial is an international, open label, randomized controlled trial comparing rituximab with azathioprine as maintenance therapy in relapsing ANCA-associated vasculitis. Rituximab is now established as an effective drug for anti-neutrophil cytoplasmic antibody (ANCA) vasculitis following major European and US trials reported in 2010. After a time, its effect wears off and the disease more »

Mepolizumab Trial for EGPA/CSS Patients Now Enrolling

The purpose of this randomized, double-blind study is to investigate the efficacy and safety of mepolizumab (300 milligram mg administered subcutaneously every four weeks) compared with a placebo over a 52-week study treatment period in subjects with relapsing or refractory Eosinophilic granulomatosis with polyangiitis (EGPA/Churg Strauss syndrome) receiving standard of care therapy including background corticosteroid more »

PROMIS – Quality of Life Survey

 Vivek Nagaraja, MD and Dinesh Khanna, MD, MSc at the University of Michigan Health System, are conducting a piece of research called PROMIS (Patient Reported Outcomes Measurement Information System) in rheumatology. The research involves an online survey catered to patients with various rheumatologic conditions. Interested patients are highly encouraged to take this survey as it more »

VCRC Genetic Repository One-Time DNA Study

The Vasculitis Clinical Research Consortium is pleased to let you know the University of Michigan, Ann Arbor is now enrolling patients for our study: VCRC Genetic Repository One-Time DNA Study About this study ~ The purpose of this study is to identify genes that increase the risk of developing vasculitis. A total of 1,300 subjects more »

AAV Patients and Volunteers needed for a Clinical Trial in Vasculitis

Patients with anti-neutrophil cytoplasm antibody (ANCA)-associated Vasculitis (AAV) are at risk of disease relapse and so are often kept on long-term medication that suppresses their immune system. These medications may have possible long term harmful effects, but it is hard to tell when to stop treatment without risking disease relapse. We are conducting an international more »

New VCRC Trial Enrolling Patients Now! The Assessment of Prednisone in Remission (TAPIR) Trial

This is a trial for patients with granulomatosis with polyangiitis (Wegener’s). You are invited to participate in a clinical trial being conducted by the Vasculitis Clinical Research Consortium (VCRC) under the direction of Dr. Peter Merkel, from the University of Pennsylvania Medical Center and VCRC Investigators at the University of South Florida. Purpose and Background more »

GiACTA Study Enrolling Patients – Giant Cell Arteritis Clinical Research Study

double vision? headaches? jaw pain? fever? fatigue? About this Study Giant cell arteritis is a disease where blood vessels become inflamed causing symptoms such as headaches, head tenderness, vision difficulties, facial pain, jaw pain, and fever. Local doctors are conducting this clinical research study for people with giant cell arteritis or GCA. This study is testing the safety more »

Cedars-Sinai Medical Center in Los Angeles, CA is conducting several research studies that involve collecting data to better understand the genetics, environmental risks, and outcomes of patients with all forms of Vasculitis

ACR/EULAR endorsed study to develop classification and diagnostic criteria for primary systemic Vasculitis (DCVAS) Background The purpose of this study is to develop new methods of diagnosing and classifying vasculitis. In order to do this, we need to collect information from two groups of people: patients who have vasculitis and patients who have diseases that more »

PEXIVAS

PEXIVAS: An International Randomized Controlled Clinical Trial Assessing Plasma Exchange and Steroid Dosing in the Treatment of Severe Anti-Neutrophil Cytoplasm Antibody (ANCA) Associated Vasculitis Introduction: The PEXIVAS study is the largest clinical trial ever to be conducted for vasculitis. The study will study 500 patients with ANCA-associated vasculitis with granulomatosis (Wegener’s) or microscopic polyangiitis and more »

Longitudinal Protocol for Granulomatosis with Polyangiitis (Wegener’s) and Microscopic Polyangiitis

5505: Longitudinal Protocol for Granulomatosis with Polyangiitis (Wegener’s) and Microscopic Polyangiitis Status: Recruiting Summary: Vasculitis Clinical Research Consortium 5505: In the longitudinal studies, clinical and laboratory information will be collected on patients with vasculitis to study the disease over an extended period of time. The data from the longitudinal studies will be used by scientists more »

Longitudinal Protocol for Polyarteritis Nodosa

Vasculitis Clinical Research Consortium 5504: Longitudinal Protocol for Polyarteritis Nodosa Status: Recruiting Summary: In the longitudinal studies, clinical and laboratory information will be collected on patients with vasculitis to study the disease over an extended period of time. The data from the longitudinal studies will be used by scientists to study the genetics and causes more »

VCRC Genetic Repository One-Time DNA Study

Vasculitis Clinical Research Consortium 5510: Churg-Strauss syndrome (CSS), giant cell arteritis (GCA), microscopic polyangiitis (MPA), polyarteritis nodosa (PAN), Takayasu’s arteritis (TAK), and Wegener’s granulomatosis (WG) Background The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will more »

Longitudinal Protocol for Churg-Strauss Syndrome

Vasculitis Clinical Research Consortium 5506: Longitudinal Protocol for Churg-Strauss Syndrome Status: Recruiting Summary:  In the longitudinal studies, clinical and laboratory information will be collected on patients with vasculitis to study the disease over an extended period of time.  The data from the longitudinal studies will be used by scientists to study the genetics and causes of vasculitis, more »

Longitudinal Protocol for Giant Cell Arteritis

Vasculitis Clinical Research Consortium 5502: Longitudinal Protocol for Giant Cell Arteritis Status: Recruiting Summary:  In the longitudinal studies, clinical and laboratory information will be collected on patients with vasculitis to study the disease over an extended period of time.  The data from the longitudinal studies will be used by scientists to study the genetics and causes of more »

Concurrent Pilot Studies in Giant Cell Arteritis and Takayasu’s Arteritis (AGATA)

Vasculitis Clinical Research Consortium 5523: Concurrent Pilot Studies in Giant Cell Arteritis and Takayasu’s Arteritis to Examine the Safety, Efficacy, and Immunologic Effects of Abatacept (CTLA4-Ig) in Large Vessel Vasculitis (AGATA) Status: Recruiting Background Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are types of vasculitis that affect large arteries and may involve vessels that supply blood more »

VCRC Imaging Protocol for Magnetic Resonance and Positron Emission Tomography in Large-Vessel Vasculitis

Vasculitis Clinical Research Consortium  5515: VCRC Imaging Protocol for Magnetic Resonance and Positron Emission Tomography in Large-Vessel Vasculitis (Takayasu’s Arteritis): Development as Clinical Trial Outcome Measures Status: Recruiting Background Takayasu’s arteritis is a rare disease that affects the blood vessels. Takayasu’s arteritis can cause swelling of large and medium-sized blood vessels. The blood vessels that are commonly more »

Longitudinal Protocol for Takayasu’s Arteritis

Vasculitis Clinical Research Consortium 5503: Longitudinal Protocol for Takayasu’s Arteritis Status: Recruiting Summary: Vasculitis Clinical Research Consortium 5503. In the longitudinal studies, clinical and laboratory information will be collected on patients with vasculitis to study the disease over an extended period of time. The data from the longitudinal studies will be used by scientists to study the more »