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Now Enrolling: A Randomized Multicenter Study for Isolated Skin Vasculitis (ARAMIS)

The purpose of the ARAMIS Study is to evaluate different treatment options for patients with skin vasculitis (also called cutaneous vasculitis).

Patients with small- or medium-vessel vasculitis that only involves the skin (“isolated skin vasculitis”), including some forms of polyarteritis nodosa or IgA vasculitis (Henoch-Schönlein purpura) can join this study.

There is not a common preferred or recommended treatment option for isolated skin vasculitis, and different doctors may advise using different drugs, based only on their personal experience. The most frequently used treatments for skin vasculitis are colchicine, dapsone and azathioprine. This study will compare how effective these three drugs are at treating isolated cutaneous vasculitis.

For Diseases
› Isolated cutaneous small-vessel (SVV)
› Isolated cutaneous medium-vessel vasculitis (MVV)
› Cutaneous polyarteritis nodosa (cPAN)
› IgA vasculitis (Henoch-Schönlein purpura, IgAV)

About this Study
About 90 people with skin vasculitis will take part in this study. If you take part in this study, you will be asked to complete a minimum of 6 study visits at the study site.

The number of visits will depend upon which stage you enroll into the study and how your skin vasculitis responds to the treatments. You may be in this study for up to 18 months.

In order to participate in a study, you must personally contact the study coordinator of any of the participating institutions by phone or by e-mail.

Please use the information below to inquire about participation.
› University of Pennsylvania, Philadelphia
› Study Coordinator: Christopher Snider, MPH [email protected]
› Phone: 215.662.6597
Source: www.rarediseasesnetwork.org/cms/vcrc/ Research/Studies/5562

The ARAMIS Study site list includes:
• University of Kansas Medical Center, Kansas City
• Boston University School of Medicine, Boston
• Mayo Clinic, Rochester
• Hospital for Special Surgery, New York City
• Northwell Health, Lake Success
• Cleveland Clinic, Cleveland
• Oregon Health & Science University, Portland
• Penn State Hershey Medical Center, Hershey
• University of Pennsylvania, Philadelphia
• University of Utah, Salt Lake City

• St. Joseph’s Healthcare, Hamilton
• University of Toronto Mount Sinai Hospital, Toronto