What is the difference between systemic polyarteritis nodosa (PAN) and cutaneous PAN?

Polyarteritis nodosa (PAN) is a vasculitis affecting medium-sized blood vessels. In patients with “cutaneous polyarteritis nodosa”, the findings of the disease are localized to the skin (purpura or subcutaneous nodules), but also sometimes the peripheral nerve(s) of the same limb (causing weakness and/or numbness). Patients with systemic polyarteritis nodosa have involvement of other organs, including the gastrointestinal tract, heart and/or kidneys. The systemic form is therefore usually most severe and requires stronger treatment.

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