In ANCA-associated vasculitis (EGPA, GPA and MPA), do increases in the ANCA predict disease relapse?

A general and over-simplified answer is: no. This answer is based on the statistical analysis of large groups of patients followed prospectively in clinical trials. The results from these studies have led to the general opinion held by vasculitis experts that treatment decisions should not be made based on changes…...

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Do increases in the sedimentation rate or C-reactive protein predict relapse of vasculitis?

Increases in the sedimentation rate and/or C-reactive protein do not predict disease relapses. The sedimentation rate, more formally termed the erythrocyte sedimentation rate, also known as the “ESR” or “sed rate,” and the C-reactive protein (or “CRP”) are non-specific markers of inflammation. They are usually, but not always, elevated at…...

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What are the chances that my newly diagnosed vasculitis will relapse?

The term “relapse” is used to indicate disease related inflammation that has the potential to cause organ injury and requires treatment. Determination of a relapse is based upon the finding of disease-related inflammation. The evidence for this comes from review of symptoms, physical examination, laboratory tests, and sometimes imaging studies.…...

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What triggers disease relapses (flares)?

The triggers for disease relapses are unknown. While many questions have appropriately been raised about factors such as infection and stress, no definitive association between these or other possible triggers have been found to be linked with disease relapses. If I have a relapse after achieving remission is it likely…...

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What is remission?

“Remission” is a term used to indicate that there is no longer any detectable inflammatory disease activity. The use of the term “remission” implies that the disease may not be cured, and that relapses are possible in the future. Once a state of remission has been achieved the intensity of…...

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