What is steroid myopathy?

Prednisone directly causes atrophy of muscle fibers (myopathy) leading to muscle weakness.  This is a very common side effect of chronic (a few months or more) prednisone use but can be either mild or severe.  Patients usually notice weakness most in the upper legs.  It is not a painful condition…...

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How long does prednisone stay in your system?

The drug is “out of your system” within a day, but the side effects that have accumulated over time (weight gain, diabetes, round face, easy bruising, muscle weakness, osteoporosis) can take a long time to reverse, and some may not revere (stretch marks, cataracts).  Risk of infection probably goes down…...

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Do patients taking prednisone need to be on treatment for osteoporosis?

Long-term treatment with prednisone, even at relatively low doses, is associated with bone loss and is considered a risk factor for bone fractures even with a normal bone density test.  All patients treated with prednisone should be on supplemental calcium (1000-1200 mg daily) and vitamin D (800 IU daily) therapy…...

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In EGPA/Churg Strauss syndrome do increases in the eosinophil count predict relapse?

We do not have very good data to tell us what the most reliable markers of disease activity or predictors of relapse in EGPA are. Eosinophils are one of the subtypes of white blood cells and the level of eosinophils can be measured in the blood. In addition to a…...

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How do I predict relapse in EGPA/Churg Strauss syndrome?

It can be hard to determine relapses in EGPA/Churg Strauss syndrome. A return of sinus symptoms and asthma is very common, but these but may not represent active vasculitis. These symptoms may require treatment with prednisone and are commonly the rate-limiting features in being able to reduce the prednisone dose…...

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