What are the chances of recovering lost hearing in a patient with GPA?

Hearing can be transiently decreased in patients with GPA with acute otitis, because of the presence of liquid in the inner ear(s), which will regress under appropriate treatment. However, when the inner ear damage is severe, because of prolonged or multiple recurrences of otitis, and/or when the auditory nerve(s) are…...

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Can you still be diagnosed with Granulomatosis with polyangiitis (GPA, formerly Wegener’s) if the ANCA is negative?

Yes. Although ANCA is elevated in a majority of patients with granulomatosis with polyangiitis (GPA, formerly called Wegener’s), it is not detectable in all patients and is not necessary to make the diagnosis....

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What is the difference between ANCA and ANA?

Both are blood tests used by doctors to help in the diagnosis of autoimmune disease. Antineutrophil cytoplasmic antibody (ANCA) is a blood test commonly elevated in patients with diseases such granulomatosis with polyangiitis, microscopic polyangiitis, and EGPA/Churg-Strauss syndrome. Antinuclear antibody (ANA) is a blood test most often elevated in patients…...

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What is the difference between limited and severe granulomatosis with polyangiitis (GPA, formerly Wegener’s)?

Not all patients with granulomatosis with polyangiitis (GPA) have similar disease. The term “limited” GPA was introduced in 1966 and was originally defined as GPA that did not involve the kidneys. Unfortunately, this term has often been misinterpreted. “Limited” GPA is not equivalent to non-severe GPA as there are people…...

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What does the word polyangiitis mean? (related to the name change).

“Poly” indicates that many blood vessels are involved, and “angiitis” is used instead of “arteritis” because granulomatosis with polyangiitis (Wegener’s) and microscopic polyangiitis affect the smallest vessels in the body (arterioles, capillaries, and venules), all of which are smaller than arteries. In contrast, in polyarteritis nodosa, giant cell arteritis, and…...

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