How long does prednisone stay in your system?

The drug is “out of your system” within a day, but the side effects that have accumulated over time (weight gain, diabetes, round face, easy bruising, muscle weakness, osteoporosis) can take a long time to reverse, and some may not revere (stretch marks, cataracts).  Risk of infection probably goes down quickly after stopping prednisone, but the exact timing is not known.

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