Do increases in the sedimentation rate or C-reactive protein predict relapse of vasculitis?

Increases in the sedimentation rate and/or C-reactive protein do not predict disease relapses. The sedimentation rate, more formally termed the erythrocyte sedimentation rate, also known as the “ESR” or “sed rate,” and the C-reactive protein (or “CRP”) are non-specific markers of inflammation. They are usually, but not always, elevated at the time of vasculitis relapse, but not necessarily before the relapse. Since they are non-specific markers, they can be elevated in any condition associated with inflammation ranging from any type of infection to surgical procedures. The sedimentation rate can also be high in patients with renal insufficiency or anemia. Decisions about treatment should not be made based on the sedimentation rate and C-reactive protein alone.

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