In theory, vasculitis caused by immune complexes (cryoglobulinemia, polyarteritis nodosa, Henoch-Schoenlein purpura, and vasculitis associated with rheumatoid arthritis, lupus, or Sjogren’s syndrome) could get either better or worse with IVIG. Worsening of cryoglobulinemic vasculitis after IVIG (or rituximab, for the same reason) has been reported....
Mepolizumab: What is the toxicity of this drug? Side effects? Effects on pregnancy? What is the drug indicated for now?
This drug is still considered investigational and is not generally available. It has been studied in small numbers of patients with Churg-Strauss syndrome and hypereosinophilic syndromes, and although it has appeared safe in these studies, the numbers of patients are too small to draw any conclusions about safety and side…...