Registration is now open for Rare Disease Day at the National Institutes of Health (NIH). The aim of Rare Disease Day is to raise awareness about rare diseases, the people they affect, and NIH research collaborations underway to address scientific challenges and to advance new treatments. Speakers include Noah Victoria, a rare disease patient who will share her story; founders of several organizations dedicated to rare diseases treatment; researchers and staff at children’s hospitals across the United States, and leadership from NCATS and other NIH Institutes and Centers. The event will feature personal and scientific stories about rare diseases and interactive panel discussions on individualized therapies and personalized medicine for rare diseases, shortening the often lengthy and complicated journey to find a diagnosis, and expanding and improving access to rare diseases information. Other highlights include an NIH Town Hall Question and Answer Session, posters and exhibits, artwork, and tours of the NIH Clinical Center.