ANCA-associated Vasculitis

An August 2020 article in Nature Reviews discusses the many aspects of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)—a group of autoimmune diseases (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis) that causes blood vessels to swell. The vessels involved in AAV are typically capillaries, arterioles and venules but small…...

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ChemoCentryx Announces Publication in The New England Journal of Medicine of Results of the Pivotal Phase III ADVOCATE Trial of Avacopan for the Treatment of ANCA-Associated Vasculitis

February 17, 2021 17:00 ET | Source: ChemoCentryx, Inc. — Treatment with avacopan in the absence of daily oral prednisone led to remission at week 26 and superiority in sustaining remission at 52 weeks compared to the prednisone group — — Avacopan’s effects on kidney function, patient Quality of Life,…...

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VF Awards Research Grant to Pulmonary/Critical Care Medicine Physician at OSU

Lynn A. Fussner, MD, Assistant Professor at The Ohio State University (OSU), Division of Pulmonary, Critical Care, and Sleep Medicine, has been awarded a one-year grant from the Vasculitis Foundation (VF) for her study, “Role of Monocytes and Alpha-1 Antitrypsin in ANCA-Associated Vasculitis.” Dr. Fussner’s goal is to identify better…...

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Pitt Scientists Identify Genetic Risks of Rare Inflammatory Disease

PITTSBURGH, Dec. 11, 2020 – In a paper published today in the American Journal of Human Genetics, a group of international collaborators led by researchers from the University of Pittsburgh School of Medicine identified new genetic associations that can predict individual susceptibility to a rare inflammatory disease called Takayasu arteritis.…...

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Scientists use Clues in the Human Genome to Discover new Inflammatory Syndrome

“Our team of researchers at the NIH discovered a new form of vasculitis  and called it VEXAS. VEXAS is caused by genetic mutations in a portion  of a patient’s blood cells. Before we knew about VEXAS, these patients were diagnosed with other forms of vasculitis, such as relapsing polychondritis, polyarteritis…...

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