Research Program

Purpose

The VF Research Program provides one- or two-year seed grants to support pilot studies in researching:

  • Etiology/Pathogenesis (could include a broad range of studies of immunity, inflammation, or vascular biology. Relevance to human vasculitis will be taken into account by the reviewers.)
  • Epidemiology, including genetics
  • Diagnosis, including identification of disease subtypes
  • Treatment/Management, including therapeutics to treat vasculitis or prevent complications, biomarkers, and psychosocial outcomes

Goals

To improve the quality of life for patients with vasculitis and ultimately find the cause/s and cure for vasculitis.

Funding

The Research Program is funded by donations and special fundraising events, organized by people like YOU.

Maximum Awards

$50,000 for 12 months. Some awards will be available for two years at a maximum of $50,000 per year.  Among applications with similar scores, preference will be given to applications with total budgets of $50,000 or less, to ensure that the Foundation can support as many investigators, and as many approaches to research in vasculitis as possible. . The Foundation’s hope is that the results of the research supported by the Research Program will lead to, and provide the basis for, much larger multi-year studies that would be funded by larger agencies such as The US National Institutes of Health (NIH).

International Funding Available

The VF Research Program funds research worldwide.

Applications are reviewed annually. The deadline for submitting applications for the 2016 funding cycle is Tuesday, September 8, 2015.  Awards will be announced in December with funding available early in 2016.

New Application Process

We are pleased to introduce our new online application process.  The online application will allow you to review the program’s guidelines, copy/paste information into the text boxes and upload files, appendices and supporting documents as needed.  You can also save the application and come back to it as many times as you want before submitting.  Click here to access the online portal

IF you have any questions or problems with the application process, please contact Joyce A. Kullman, VF Executive Director. 

New Application Deadline

Due to the delay in launching the new online application process, we are extending the application deadline to Tuesday, September 8, 2015 at midnight CDT.


 2012 Consensus Conference

The Vasculitis Foundation hosted the 2nd International Vasculitis Research Consensus Conference on Friday, April 20, 2012, at the Hilton Chicago, Illinois. Dr. Gary S. Hoffman, Cleveland Clinic Center for Vasculitis Care and Research, functioned as the program moderator and facilitator.

The purpose of the conference was to utilize the combined skills and experience of leading experts in vasculitis from different subspecialties and other scientific fields to evaluate the VF Research Program and explore new areas of inquiry that the Foundation should support over the next five years.

Click here to download the VF Research Consensus Conference Report 2012.


Grants awarded by the Vasculitis Foundation

2015 Grants

Immune Regulation by IL-6 in Giant Cell Arteritis, $50,000
Jonathan Choy, PhD, Simon Fraser University, Burnaby, British Columbia Canada

Longitudinal Study of Morbidity and Mortality in Vasculitis Patients, $98,641 (two-year study)
Susan Jick, DSc, Professor of Epidemiology, Director Boston Collaborative Drug Surveillance Program Boston University School of Public Health, Boston, Massachusetts

Role of LAMP-2 in Tolerance to ANCA Antigens, $50,000
Renate Kain, MD, PhD, Medical University of Vienna, Vienna, Austria


2014 Grants

The Role of micro RNA in a Novel Mouse Model of Vasculitis, $50,000
Carola G. Vinuesa, MD, MSc, PhD, John Curtin School of Medical Research The Australian National University, Canberra City, Australia

Rho-kinase Activity in Large Vessel Vasculitis, $50,000
Lindsay Lally, MD, principal investigator, Rheumatology Fellow; Robert Spiera, MD, co-investigator, Hospital for Special Surgery, New York 

Microbubble Contrast-Enhanced Vascular Ultrasonography: A Novel Method of Detecting Large Vessel Vasculitis? $50,000
Kimberly P. Liang, MD, Assistant Professor of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania


2013 Grants

Circulating microparticles as therapeutic targets of plasma exchange in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis, $99,206 (two years)
Paul Brogan, FRCPCH, reader in vasculitis and honorary consultant pediatric rheumatologist, UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom 

To Understand the Role of 14-3-3 In Giant Cell Arteritis (GCA), $50,000
Ritu Chakravarti, Ph.D., research associate, Department of Pathobiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio

Disease-specific dysregulation of miRNA in Granulomatosis with Polyangiitis (GPA/Wegener’s), $50,000
Susanne Schinke, MD, research fellow, Department of Rheumatology and Clinical Immunology, The University of Lübeck, Germany

Development of a uniform histology scoring systems for Small Vessel CNS Vasculitis in adulthood and childhood, $40,128
Susanne Benseler, MD, pediatric rheumatologist, associate professor of paediatrics, The Hospital for Sick Children, University of Toronto, Canada


2012 Grants

Impact of Healthcare Utilization & Informal Caregiving for Primary Systemic Vasculitis: A National Perspective, $99,920
Carolyn T. Thorpe, PhD, MPH, Pharmacy and Therapeutics, University of Pittsburgh, Pennsylvania

Exome sequencing in granulomatosis with polyangiitis (GPA, Wegener’s), $50,000
Sharon Chung, MD, MAS, Division of Rheumatology, University of California, San Francisco

Investigating the molecular mechanism for IL-25-driven Act 1-dependent eosinophilic vasculitis, $50,000
Shadi Swaidani, PhD, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio

Small molecule therapeutics in Giant Cell Arteritis, $50,000
Cornelia Weyand, MD, PhD, Stanford University School of Medicine, California


2011 Grants

Defining an animal model for the study of Wegener’s Granulomatosis, $75,000
Felipe Andrade, MD, PhD, The Johns Hopkins University, Baltimore, Maryland


2010 Grants

Reproductive Health in Young Men and Women with Vasculitis, $49,978
Megan E. B. Clowse, MD, Rheumatology and Immunology, Duke University, Raleigh, North Carolina

Classification and Diagnostic Criteria in Primary Systemic Vasculitis, $99,738
Raashid Ahmed Luqmani, MD, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Science Oxford, England

Identification of susceptibility genes in Takayasu’s arteritis, $50,000
Amr H. Sawalha, MD, Oklahoma City, Oklahoma


2009 Grants

PARP-1 in CSS-associated IL-10 Promoter Polymorphisms, $50,000
Jianguo Liu, MD, PhD, Division of Immunobiology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri


2008 Grants

Vasculitic T Cells in Giant Cell Arteritis, $99,583 
C.M. Weyand, MD, Emory University, Atlanta, Georgia

An Investigation of the Role of the Innate Immune Response in Kawasaki Disease, $49,980
Neil Bowles, PhD, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah

Investigating the role of the novel Th 17 cells in the pathogenesis of ANCA associated vasculitis and their potential for immunomodulation, $48,000
Alan Salama, MBBS, PhD, FRCP, Renal Section, Division of Medicine Imperial College London, England


2007 Grants
ANCA Vasculitis:  Autoimmune B Cell dysregulation and its Clinical Impact, $50,000
Patrick Nachman, MD, University of North Carolina Kidney Center, Chapel Hill, North Carolina
Expression and activation of p38MAPK isoforms in ANCA-associated renal vasculitis, $50,000
Jochen Zwerina, MD, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen, Germany

2006 Grants

Identification and characterization of immunodominant, conformational epitopes of antineutrophil cytoplasmic antibodies, $35,000
Antje Mueller, MD, Csernok, MD, Peter Lamphrect, MD, University of Rheumatology, University Hospital Schleswig-Holstein, Campus Lubeck, Germany

Gene Expression Profile of Temporal Arteries of Giant Cell Arteritis, $35,000
Rula Hajj-Ali, MD, Cleveland Clinic, Cleveland, Ohio


2005 Grants

Environmental Factors in the Pathogenesis of Wegener’s Granulomatosis, $35,000
Daniel Albert, MD, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Localized Wegener’s Granulomatosis: Epidemiological, clinical and histopathological characteristics, $30,000
Peer Malte Aries, MD, and Prof. Wolfgang L. Gross, MD, Department of Rheumatology, University Hospital of Schleswig-Holstein

A Pilot Project Towards Establishment of a US/Canadian Diagnostic Registry of  Children with Wegener’s Granulomatosis and Related Vasculitides, $34,900
David A. Cabral, MBBS, BC Children’s Hospital, Vancouver, British Columbia, Canada

Renal transplantation in Wegener’s granulomatosis: mortality, allograft outcomes  and incidence of malignancies from the United Network for Organ Sharing database 1988-2005, $16,000
Nadine Tanenbaum, MD, Duke University, Raleigh, North Carolina


2004 Grants

Identification of novel Wegener’s Granulomatosis Susceptibility Genes, $35,000

Katherine Siminovitch, PhD,  Mount Sinai Hospital, Toronto, Ontario, Canada

Wegener’s Granulomatosis and Microscopic Polyarteritis Case Control Study in Western Montana, $7,500
Andrew Zeft, MD, Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah

Development of a Measure to Assess Patients’ Adherence to Vasculitis Treatment Regimens, $35,000
Robert DeVellis, PhD, Associate Director, Arthritis Multidisciplinary Clinical Research Center, University of North Carolina, Chapel Hill, North Carolina

Analysis of NKG2D expression on CD28- T-cells and non-classical MHC-class I antigen expression on antigen-presenting cells as clues to an antigen-driven process and new targets of treatment in Wegener’s granulomatosis, $35,000
Prof. Wolfgang L. Gross, MD, and Peter Lamprecht, MD, Department of Rheumatology, University Hospital of Schleswig-Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Germany


2003 Grants

The role of shear stress in neutrophil proteinase-3 expression and its importance in vascular injury sites in Wegener’s granulomatosis, $35,000
Deborah Stearns-Kurosawa, PhD, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma


2002 Grants

Host-microbial interactions in Wegener’s Granulomatosis: the role of ANCA and S. aureus persistence, $35,000
Robert Inman, MD, University of Toronto, Canada

Short-Term Cyclophosphamide Therapy in a Cohort of Over 200 Patients, $35,000
Gary Hoffman, MD, MS and Alexandra Villa-Forte, MD, MPH, The Cleveland Clinic, Cleveland, Ohio