Rituximab for ANCA-Associated Vasculitis (RAVE) Study

Enrollment is Open: Participants Needed

Sponsored by The National Institute of Allergy and Infectious Disease and The Immune Tolerance Network

A randomized, multicenter trial for patients with severe ANCA-associated vasculitis.

Participants will be randomized to either a treatment of cyclophosphamide (CYC) and prednisone or rituximab and prednisone.

The primary objective of this trial is to determine the efficacy of rituximab and glucocorticoids in the induction of remission of ANCA-associated vasculitis.

For further detailed information: http://vasculitis.med.jhu.edu

Study Coordinators:

Lourdes Sejismundo (410) 550-6818 or

Yavette Goldsborough (410) 550-4580

Email: jhvc@jhmi.edu

Lead Investigators:

Ulrich Specks, M.D.,

Division of Pulmonary and Critical Care, Mayo Clinic

Co-directors: Philip Seo, M.D./Stuart Levine, M.D.,

The Johns Hopkins Vasculitis Center

Participating Medical Centers

Boston University

Cleveland Clinic

Duke University

Hospital for Special Surgery, New York City

Mayo Clinic

The Johns Hopkins Vasculitis Center

University of Alabama at Birmingham