Defining Mechanisms of atherosclerosis in Wegener’ Granulomatosis

This study looks at causes of atherosclerosis (hardening of the blood vessels) in patients with Wegener’s Granulomatosis. The study entails collection of clinical information, and blood samples. In addition all patients with Wegener’s Granulomatosis will undergo ultrasound of the carotid arteries to assess for hardening of these vessels located in the neck.  By correlating clinical information with findings from the research blood and ultrasound, scientists may be able to study the reasons of atherosclerosis (hardening of the vessels) in Wegener’s Granulomatosis. 

Population needed:  Patients older than 18 years of age with Wegener’s Granulomatosis; patients who are in remission with no previous diagnosis of heart failure, blockage of the arteries (heart or leg arteries), or stroke are welcome to participate.  Candidates will be screened with a history and physical examination, blood tests for research purposes and for lipids and fasting sugar measurements and ultrasound of the carotids. Patients or their third party payers will not be responsible for any cost which is out of the standard care.   

WHO CAN PARTICIPATE IN THIS RESEARCH STUDY? 

·        Age >18 years old.

·     An established diagnosis of Wegener Granulomatosis, currently in remission.

·        The ability to understand and sign informed consent.

·        Normal kidney function.  

YOU MAY NOT PARTICIPATE IN THIS STUDY IF YOU HAVE:

·        Diagnosis of heart disease, stroke, or blockage of arteries in the legs.

·        Recent infection.

·        Diagnosis of chronic inflammatory diseases other than Wegener's Granulomatosis.

·        Diagnosis of Cancer or clotting tendency.  

WHAT IS INVOLVED?

  • One visit is required. An interview with physician for medical history and measurement of waist to hip length.
  • Blood samples will be drawn and ultrasound of the neck vessels will be performed.
  • Stop Aspirin and other Non-steroidal anti-inflammatory medication for a week prior to the enrollment.

If you are interested in participating please contact:

 Rula Hajj-Ali, MD at 216.444.9643 

Cleveland Clinic Center for Vasculitis Care and Research

Cleveland, Ohio USA